P-191: A Comparison of The Effects of Transdermal Estradiol and Estradiol Valerate on Endometrial Receptivity in Frozen-Thawed Embryo Transfer Cycles: A Randomized Clinical Trial
نویسندگان
چکیده مقاله:
Background: The aim of this prospective randomized clinical trial was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in FET cycles, that is, oral estradiol and 17 β-estradiol transdermal patch. Materials and Methods: A total number of 90 patients were scheduled for FET. In the study group (n=45), 17-B estradiol transdermal patches 100 μg were applied from the second day of the cycle and continued every other day. Then each patch was removed after four days. In the control group (n=45), oral estradiol valerate 6 mg started as the same time above and continued daily. Results: There was a significant difference in estradiol level on the day of progesterone administration and the day of embryo transfer between the two groups (p=0.001 in both), but no significant difference was observed between them in biochemical and clinical pregnancy rates (32.6 vs. 33.3%, p=1, 30.2 vs. 33.3%, p=0.81 respectively). The implantation rate tended to be higher in the study group, but it did not achieve a statistical significance. (20.45 vs. 11.7% respectively, p>0.05). Conclusion: In spite of no significant differences in implantation, biochemical and clinical pregnancy rates between the two groups; we can use estradiol transdermal patches instead of oral estradiol in FET cycles. This is due to the reduced costs, drug dose, and emotional stress as well as the simplicity of the protocol for patient.
منابع مشابه
a comparison of the effects of transdermal estradiol and estradiol valerate on endometrial receptivity in frozen-thawed embryo transfer cycles: a randomized clinical trial
background: the purpose of this study was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in frozen-thawed embryo transfer (fet) cycles, including that is, oral estradiol and 17ß-estradiol transdermal patch. methods: in this randomized controlled trial, women underwent either conventional ivf or intracytoplasm...
متن کاملA Comparison of the Effects of Transdermal Estradiol and Estradiol Valerate on Endometrial Receptivity in Frozen-thawed Embryo Transfer Cycles: A Randomized Clinical Trial
BACKGROUND The purpose of this study was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in frozen-thawed embryo transfer (FET) cycles, including that is, oral estradiol and 17ß-estradiol transdermal patch. METHODS In this randomized controlled trial, women underwent either conventional IVF or intracytoplasm...
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effect of sildenafil citrate on endometrial preparation and outcome of frozen-thawed embryo transfer cycles: a randomized clinical trial
background: sildenafil citrate may increase endometrial thickness and affect the outcome of frozen-thawed embryo transfer cycles. objective: the aim of this study was to estimate the effect of sildenafil citrate on ultrasonographic endometrial thickness and pattern and to investigate the estrogen level on the day of progesterone administration, the implantation rate and chemical pregnancy rate ...
متن کاملEffect of sildenafil citrate on endometrial preparation and outcome of frozen-thawed embryo transfer cycles: a randomized clinical trial
BACKGROUND Sildenafil citrate may increase endometrial thickness and affect the outcome of frozen-thawed embryo transfer cycles. OBJECTIVE The aim of this study was to estimate the effect of sildenafil citrate on ultrasonographic endometrial thickness and pattern and to investigate the estrogen level on the day of progesterone administration, the implantation rate and chemical pregnancy rate ...
متن کاملP-203: The Impact of Low-Dose Aspirin on Clinical Reproductive Outcomes in Frozen- Thawed Embryo Transfer Cycles; A Randomized, Placebo-Controlled Double- Blind Study
Background: The objective of this study is to evaluate whether low-dose aspirin affects doppler sonographic parameters of the uterine arteries, endometrial thickness and pregnancy rate of women undergoing frozen-thawed embryo transfer cycles. Materials and Methods: This randomized, double- blind, placebo-controlled trial study was conducted between April 2012, and March 2013. A total of 60 elig...
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عنوان ژورنال
دوره 8 شماره 2.5
صفحات 202- 202
تاریخ انتشار 2014-07-01
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